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Aspartame: What You Don't Know Can Hurt You
Aspartame is, by far, the most dangerous substance on the market that is added to foods.
by: Dr. Joseph Mercola


Aspartame is the technical name for the brand names NutraSweet, Equal, Spoonful, and Equal-Measure. It was discovered by
accident in 1965 when James Schlatter, a chemist of G.D. Searle Company, was testing an anti-ulcer drug.

Aspartame was approved for dry goods in 1981 and for carbonated beverages in 1983. It was originally approved for dry goods
on July 26, 1974, but objections filed by neuroscience researcher Dr John W. Olney and Consumer attorney James Turner in
August 1974 as well as investigations of G.D. Searle's research practices caused the U.S. Food and Drug Administration (FDA)
to put approval of aspartame on hold (December 5, 1974). In 1985, Monsanto purchased G.D. Searle and made Searle
Pharmaceuticals and The NutraSweet Company separate subsidiaries.

Aspartame accounts for over 75 percent of the adverse reactions to food additives reported to the FDA. Many of these reactions
are very serious including seizures and death.(1) A few of the 90 different documented symptoms listed in the report as being
caused by aspartame include: Headaches/migraines, dizziness, seizures, nausea, numbness, muscle spasms, weight gain,
rashes, depression, fatigue, irritability, tachycardia, insomnia, vision problems, hearing loss, heart palpitations, breathing
difficulties, anxiety attacks, slurred speech, loss of taste, tinnitus, vertigo, memory loss, and joint pain.

According to researchers and physicians studying the adverse effects of aspartame, the following chronic illnesses can be
triggered or worsened by ingesting of aspartame:(2) Brain tumors, multiple sclerosis, epilepsy, chronic fatigue syndrome,
parkinson's disease, alzheimer's, mental retardation, lymphoma, birth defects, fibromyalgia, and diabetes.

Aspartame is made up of three chemicals: aspartic acid, phenylalanine, and methanol. The book "Prescription for Nutritional
Healing," by James and Phyllis Balch, lists aspartame under the category of "chemical poison." As you shall see, that is exactly
what it is.

What Is Aspartame Made Of?

Aspartic Acid (40 percent of aspartame)

Dr. Russell L. Blaylock, a professor of neurosurgery at the Medical University of Mississippi, recently published a book
thoroughly detailing the damage that is caused by the ingestion of excessive aspartic acid from aspartame. Blaylock makes use
of almost 500 scientific references to show how excess free excitatory amino acids such as aspartic acid and glutamic acid
(about 99 percent of monosodium glutamate (MSG) is glutamic acid) in our food supply are causing serious chronic
neurological disorders and a myriad of other acute symptoms.(3)


How Aspartate (and Glutamate) Cause Damage

Aspartate and glutamate act as neurotransmitters in the brain by facilitating the transmission of information from neuron to
neuron. Too much aspartate or glutamate in the brain kills certain neurons by allowing the influx of too much calcium into the
cells. This influx triggers excessive amounts of free radicals, which kill the cells. The neural cell damage that can be caused by
excessive aspartate and glutamate is why they are referred to as "excitotoxins." They "excite" or stimulate the neural cells to
death.

Aspartic acid is an amino acid. Taken in its free form (unbound to proteins) it significantly raises the blood plasma level of
aspartate and glutamate. The excess aspartate and glutamate in the blood plasma shortly after ingesting aspartame or
products with free glutamic acid (glutamate precursor) leads to a high level of those neurotransmitters in certain areas of the
brain.

The blood brain barrier (BBB), which normally protects the brain from excess glutamate and aspartate as well as toxins, 1) is
not fully developed during childhood, 2) does not fully protect all areas of the brain, 3) is damaged by numerous chronic and
acute conditions, and 4) allows seepage of excess glutamate and aspartate into the brain even when intact.

The excess glutamate and aspartate slowly begin to destroy neurons. The large majority (75 percent or more) of neural cells in
a particular area of the brain are killed before any clinical symptoms of a chronic illness are noticed. A few of the many chronic
illnesses that have been shown to be contributed to by long-term exposure to excitatory amino acid damage include:

  • Multiple sclerosis (MS)
  • ALS
  • Memory loss
  • Hormonal problems
  • Hearing loss
  • Epilepsy
  • Alzheimer's disease
  • Parkinson's disease
  • Hypoglycemia
  • AIDS
  • Dementia
  • Brain lesions
  • Neuroendocrine disorders
The risk to infants, children, pregnant women, the elderly and persons with certain chronic health problems from excitotoxins
are great. Even the Federation of American Societies for Experimental Biology (FASEB), which usually understates problems
and mimics the FDA party-line, recently stated in a review that:

"It is prudent to avoid the use of dietary supplements of L-glutamic acid by pregnant women, infants, and children. The existence
of evidence of potential endocrine responses, i.e., elevated cortisol and prolactin, and differential responses between males
and females, would also suggest a neuroendocrine link and that supplemental L-glutamic acid should be avoided by women of
childbearing age and individuals with affective disorders."(4)

Aspartic acid from aspartame has the same deleterious effects on the body as glutamic acid.

The exact mechanism of acute reactions to excess free glutamate and aspartate is currently being debated. As reported to the
FDA, those reactions include:(5)

  • Headaches/migraines
  • Nausea
  • Abdominal pains
  • Fatigue (blocks sufficient glucose entry into brain)
  • Sleep problems
  • Vision problems
  • Anxiety attacks
  • Depression
  • Asthma/chest tightness.
One common complaint of persons suffering from the effect of aspartame is memory loss. Ironically, in 1987, G.D. Searle, the
manufacturer of aspartame, undertook a search for a drug to combat memory loss caused by excitatory amino acid damage.
Blaylock is one of many scientists and physicians who are concerned about excitatory amino acid damage caused by ingestion
of aspartame and MSG.

A few of the many experts who have spoken out against the damage being caused by aspartate and glutamate include Adrienne
Samuels, Ph.D., an experimental psychologist specializing in research design. Another is Olney, a professor in the department
of psychiatry, School of Medicine, Washington University, a neuroscientist and researcher, and one of the world's foremost
authorities on excitotoxins. (He informed Searle in 1971 that aspartic acid caused holes in the brains of mice.)

Phenylalanine (50 percent of aspartame)

Phenylalanine is an amino acid normally found in the brain. Persons with the genetic disorder phenylketonuria (PKU) cannot
metabolize phenylalanine. This leads to dangerously high levels of phenylalanine in the brain (sometimes lethal). It has been
shown that ingesting aspartame, especially along with carbohydrates, can lead to excess levels of phenylalanine in the brain
even in persons who do not have PKU.

This is not just a theory, as many people who have eaten large amounts of aspartame over a long period of time and do not
have PKU have been shown to have excessive levels of phenylalanine in the blood. Excessive levels of phenylalanine in the
brain can cause the levels of seratonin in the brain to decrease, leading to emotional disorders such as depression. It was
shown in human testing that phenylalanine levels of the blood were increased significantly in human subjects who chronically
used aspartame.(6)

Even a single use of aspartame raised the blood phenylalanine levels. In his testimony before the U.S. Congress, Dr. Louis J.
Elsas showed that high blood phenylalanine can be concentrated in parts of the brain and is especially dangerous for infants
and fetuses. He also showed that phenylalanine is metabolised much more effeciently by rodents than by humans.(7)

One account of a case of extremely high phenylalanine levels caused by aspartame was recently published the "Wednesday
Journal" in an article titled "An Aspartame Nightmare." John Cook began drinking six to eight diet drinks every day. His
symptoms started out as memory loss and frequent headaches. He began to crave more aspartame-sweetened drinks. His
condition deteriorated so much that he experienced wide mood swings and violent rages. Even though he did not suffer from
PKU, a blood test revealed a phenylalanine level of 80 mg/dl. He also showed abnormal brain function and brain damage. After
he kicked his aspartame habit, his symptoms improved dramatically.(8)

As Blaylock points out in his book, early studies measuring phenylalanine buildup in the brain were flawed. Investigators who
measured specific brain regions and not the average throughout the brain notice significant rises in phenylalanine levels.
Specifically the hypothalamus, medulla oblongata, and corpus striatum areas of the brain had the largest increases in
phenylalanine. Blaylock goes on to point out that excessive buildup of phenylalanine in the brain can cause schizophrenia or
make one more susceptible to seizures.

Therefore, long-term, excessive use of aspartame may provid a boost to sales of seratonin reuptake inhibitors such as Prozac
and drugs to control schizophrenia and seizures.

Methanol (aka wood alcohol/poison) (10 percent of aspartame)

Methanol/wood alcohol is a deadly poison. Some people may remember methanol as the poison that has caused some "skid
row" alcoholics to end up blind or dead. Methanol is gradually released in the small intestine when the methyl group of
aspartame encounter the enzyme chymotrypsin.

The absorption of methanol into the body is sped up considerably when free methanol is ingested. Free methanol is created
from aspartame when it is heated to above 86 Fahrenheit (30 Centigrade). This would occur when aspartame-containing
product is improperly stored or when it is heated (e.g., as part of a "food" product such as Jello).

Methanol breaks down into formic acid and formaldehyde in the body. Formaldehyde is a deadly neurotoxin. An EPA
assessment of methanol states that methanol "is considered a cumulative poison due to the low rate of excretion once it is
absorbed. In the body, methanol is oxidized to formaldehyde and formic acid; both of these metabolites are toxic." They
recommend a limit of consumption of 7.8 mg/day. A one-liter (approx. 1 quart) aspartame-sweetened beverage contains about
56 mg of methanol. Heavy users of aspartame-containing products consume as much as 250 mg of methanol daily or 32 times
the EPA limit.(9)

Symptoms from methanol poisoning include headaches, ear buzzing, dizziness, nausea, gastrointestinal disturbances,
weakness, vertigo, chills, memory lapses, numbness and shooting pains in the extremities, behavioral disturbances, and
neuritis. The most well known problems from methanol poisoning are vision problems including misty vision, progressive
contraction of visual fields, blurring of vision, obscuration of vision, retinal damage, and blindness. Formaldehyde is a known
carcinogen, causes retinal damage, interferes with DNA replication and causes birth defects.(10)

Due to the lack of a couple of key enzymes, humans are many times more sensitive to the toxic effects of methanol than
animals. Therefore, tests of aspartame or methanol on animals do not accurately reflect the danger for humans. As pointed out
by Dr. Woodrow C. Monte, director of the food science and nutrition laboratory at Arizona State University, "There are no human
or mammalian studies to evaluate the possible mutagenic, teratogenic or carcinogenic effects of chronic administration of
methyl alcohol."(11)

He was so concerned about the unresolved safety issues that he filed suit with the FDA requesting a hearing to address these
issues. He asked the FDA to "slow down on this soft drink issue long enough to answer some of the important questions. It's
not fair that you are leaving the full burden of proof on the few of us who are concerned and have such limited resources. You
must remember that you are the American public's last defense. Once you allow usage (of aspartame) there is literally nothing I
or my colleagues can do to reverse the course. Aspartame will then join saccharin, the sulfiting agents, and God knows how
many other questionable compounds enjoined to insult the human constitution with governmental approval."(10) Shortly
thereafter, the Commissioner of the FDA, Arthur Hull Hayes, Jr., approved the use of aspartame in carbonated beverages, he
then left for a position with G.D. Searle's public relations firm.(11)

It has been pointed out that some fruit juices and alcoholic beverages contain small amounts of methanol. It is important to
remember, however, that methanol never appears alone. In every case, ethanol is present, usually in much higher amounts.
Ethanol is an antidote for methanol toxicity in humans.(9) The troops of Desert Storm were "treated" to large amounts of
aspartame-sweetened beverages, which had been heated to over 86 degrees F in the Saudi Arabian sun. Many of them
returned home with numerous disorders similar to what has been seen in persons who have been chemically poisoned by
formaldehyde. The free methanol in the beverages may have been a contributing factor in these illnesses. Other breakdown
products of aspartame such as DKP (discussed below) may also have been a factor.

In a 1993 act that can only be described as "unconscionable," the FDA approved aspartame as an ingredient in numerous food
items that would always be heated to above 86 degree F (30 degree C).

Diketopiperazine (DKP)

DKP is a byproduct of aspartame metabolism. DKP has been implicated in the occurrence of brain tumors. Olney noticed that
DKP, when nitrosated in the gut, produced a compound that was similar to N-nitrosourea, a powerful brain tumor causing
chemical. Some authors have said that DKP is produced after aspartame ingestion. I am not sure if that is correct. It is definitely
true that DKP is formed in liquid aspartame-containing products during prolonged storage.

G.D. Searle conducted animal experiments on the safety of DKP. The FDA found numerous experimental errors occurred,
including "clerical errors, mixed-up animals, animals not getting drugs they were supposed to get, pathological specimens lost
because of improper handling," and many other errors.(12) These sloppy laboratory procedures may explain why both the test
and control animals had sixteen times more brain tumors than would be expected in experiments of this length.

In an ironic twist, shortly after these experimental errors were discovered, the FDA used guidelines recommended by G.D.
Searle to develop the industry-wide FDA standards for good laboratory practices.(11)

DKP has also been implicated as a cause of uterine polyps and changes in blood cholesterol by FDA Toxicologist Dr.
Jacqueline Verrett in her testimony before the U.S. Senate.(13)

References

(1) Department of Health and Human Services, Report on All Adverse Reactions in the Adverse Reaction Monitoring System,
(February 25 and 28, 1994).
(2) Compiled by researchers, physicians, and artificial sweetner experts for Mission Possible, a group dedicated to warning
consumers about aspartame.
(3) Excitotoxins: The Taste That Kills, by Russell L. Blaylock, M.D.
(4) Safety of Amino Acids, Life Sciences Research Office, FASEB, FDA Contract No. 223-88-2124, Task Order No. 8.
(5) FDA Adverse Reaction Monitoring System.
(6) Wurtman and Walker, "Dietary Phenylalanine and Brain Function," Proceedings of the First International Meeting on Dietary
Phenylalanine and Brain Function., Washington, D.C., May 8, 1987.
(7) Hearing Before the Committee On Labor and Human Resources United States Senate, First Session on Examing the Health
and Safety Concerns of Nutrasweet (Aspartame).
(8) Account of John Cook as published in Informed Consent Magazine. "How Safe Is Your Artificial Sweetner" by Barbara
Mullarkey, September/October 1994.
(9) Woodrow C. Monte, Ph.D., R.D., "Aspartame: Methanol and the Public Health," Journal of Applied Nutrition, 36 (1): 42-53.
(10) US Court of Appeals for the District of Columbia Circuit, No. 84-1153 Community Nutrition Institute and Dr Woodrow Monte
v. Dr Mark Novitch, Acting Commissioner, US FDA (9/24/85).
(11) Aspartame Time Line by Barbara Mullarkey as published in Informed Consent Magazine, May/June 1994.
(12) FDA Searle Investigation Task Force. "Final Report of Investigation of G.D. Searle Company." (March 24, 1976)
(13) Testimony of Dr Jacqueline Verrett, FDA Toxicologist before the US Senate Committee on Labor and Human Resources,
(November 3, 1987).


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